RBR-8mx5g6 U1111-1121-5553 REBEC 03/07/2011 Escola de Educação Física e Esporte da Universidade de São Paulo - Brazil Influence of captopril use on blood pressure response measured after a single bout of strength exercise in men with high blood pressure Effect of captopril use on blood pressure response after a single bout of resistance exercise in hypertensive men 01/07/2011 actual 24 not yet recruiting http://www.ensaiosclinicos.gov.br/rg/RBR-8mx5g6/ Randomized controlled clinical trial, with 2 arms, phase 4, double-blinded. 4 Hypertension Groups: normotensives and hypertensives Normotensives: Evaluated without any teraphy Hypertensives: different oral therapies, administered for 4 weeks each (random and double blinded). Therapies = captopril (50-75mg, 3 times a day) and placebo (3cp/day).

public Claudia Lucia de Moraes Forjaz

Av. Prof. Mello Moraes, 65 - Butantã

São Paulo Brazil 05508030 551130913136 cforjaz@usp.br Escola de Educação Física e Esporte da Universidade de São Paulo scientific Claudia Lucia de Moraes Forjaz

Av. Prof. Mello Moraes, 65 - Butantã

São Paulo Brazil 05508030 551130913136 cforjaz@usp.br Escola de Educação Física e Esporte da Universidade de São Paulo Brazil Men Aged between 30 and 60 years Non smokers Physically inactives (did not perform physical activity more than twice a week) Normotensives and hypertensives will form different groups Hypertensives should not have end organ damage or secondary causes of hypertension according to the diagnotic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, USP. 30Y 60Y M Subjects with obesity (body mass index equal or greater than 30 kg/m2) Subjects with diabetes (fasting glycemia equal or greater than 126 mg/dl) Subjects with cardiac diseases (previous diagnosis or alteration on resting or exercise ECG) Subjects who do not tolerate the study medication C14 C14.907.489 drug other F01.145.632 D27.505.519.389.745.085 post-exercise hypotension - evaluated by the measurement of clinic (auscultatory) and ambulatorial (oscillometric) blood pressure before and after rest and resistance exercise while receiving placebo and captopril. hemodynamics - evaluated by the measurement of cardiac output (CO2 rebreathing)and heart hate (ECG) performed before and after rest and resistance exercise while receiving placebo and captopril. Systemic vascular resistance and stroke volume will be calculated. Autonomic modulation - evaluated by the measurement of heart rate and blood pressure variabilities (spectral analysis) performed before and after rest and resistance exercise while receiving placebo and captopril Vascular function - evaluated by the measurement of baseline blood flow and its response to the reactive hyperemia maneuver (venous occlusion pletismography) performed before and after rest and resistance exercise while receiving placebo and captopril. Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP - Brazil CAAE-0005.0.342.000-10 CONEP 2010/05 CEP39 Pro Reitoria de Graduação da Universidade de São Paulo - Brazil Fundação de Amparo à Pesquisa do Estado de São Paulo - Brazil